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Scientist in Rheumatology (d/w/m) Department of Rheumatology and Clinical Immunology - DM.66.24a

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Scientist in Rheumatology (d/w/m) Department of Rheumatology and Clinical Immunology - DM.66.24a

Fachgebiet
Immunologie, Rheumatologie

Jetzt bewerben
 

Arbeitszeit
Teilzeit

Eintrittsdatum
01.09.2024

Dauer der Anstellung
Befristet

Bewerbungsfrist
31.05.2024

Einsatzort Charité
Campus Charité Mitte

Kennziffer
3147

Entgeltgruppe
E13

 

Working at the Charité

Applications are invited for a project aimed at detailing the contribution of B cells in the development of rheumatoid arthritis. The successful applicant will join the laboratory of Gerhard Krönke, head of the Department of Rheumatology and Clinical Immunology at the Charité hospital, Berlin. The candidate will be based at the rheumatology research laboratory of the Charité and work in close cooperation with the German rheumatology research centre (DRFZ), both located at the Charité Campus Mitte in central Berlin. 

 

Job Overview

The laboratory of Gerhard Krönke has contributed key insights into aspects of both the innate and adaptive immune response in rheumatoid arthritis (RA) and other autoimmune diseases (including Nat Immunol 2017, J Exp Med 2017, Nature 2019, Immunity 2021, Nat Med 2022, J Exp Med 2023, Nature 2024). The group uses advanced approaches including single-cell and spatial sequence analysis, confocal and lightsheet microscopy, metabolic analysis and high-dimensional spectral flow cytometry to address this complex matter. The proximity to the clinic allows for the extensive analysis of human blood and tissue samples, including longitudinal studies. In addition, the group uses a variety of murine models of autoimmune arthritis, including reporter and (conditional) knock-out strains. 

For this project, we are searching for a motivated PhD student who will join our efforts into understanding the B cell response in  rheumatoid arthritis. Recently, the lab has made significant gains into understanding the functionality of disease-relevant B cells both systemically and in the target tissue, in patients as well as in murine models. Additionally, the group is involved in the analysis of experimental clinical therapies that target B cells and plasma cells and are showing great promise for the treatment of autoimmune disease. The challenge now is to not only understand the direct contribution of B cells to the disease pathology but also to elucidate how the development or depletion of B cells affects other components of the immune system in RA.

The qualification objective is a doctorate.

You are scientifically active: According to §110 (4), sentence 3, the BerlHG provides scientific employees with an appropriate amount of time within their working hours for their own further scientific qualification

Required

The ideal candidate should have:

  • an internationally recognised Master’s degree in a relevant topic
  • an eligibility to live and work in Germany
  • an interest in immunology and a willingness to work with both human material and animal models
  • an analytical and critical mindset.
  • experience with common immunological techniques including cell culture, flow cytometry and microscopy is highly desired. 
  • experience with single cell sequencing and data analysis as well as the possession of a FELASA B qualification would be an advantage but not essential. 
  • Excellent oral and written communication skills in English (essential) and German (advantageous) 


Advantages at the Charité

  • A highly professional collaboration in a motivated and interdisciplinary team
  • A future-oriented, varied and demanding job with a high level of personal responsibility and personal scope for action
  • Intercultural team events, well-structured onboarding with nice colleagues
  • Discounts on many offers for employees in the areas of shopping, travel and sports
  • Our company pension scheme provides our employees with additional security in old age
  • The Charité has been certified as a family-friendly university and family-friendly company since 2007 - you can find further information here

Informationen zur Stelle

  • Salary group E13 according to TVöD- VKA- K. The classification is based on qualification, the respective experience level is calculated from the years of professional experience. The annual salary (gross) is given for a full-time position without annual bonus, allowances and additional services. You can find the collective agreement here
  • The working time is part-time with 25,35 hours per week
  • At our company 30 days of vacation are standard
  • The application deadline is on: 31.05.2024
  • Reference number: 3147

Ihre Bewerbung

 

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Bei Fragen wenden Sie sich bitte an:

gerhard.kroenke@charite.de

Weitere Informationen

Datenschutzhinweise

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Zusatzinformationen

Die Charité – Universitätsmedizin Berlin trifft ihre Personalentscheidungen nach Eignung, Befähigung und fachlicher Leistung. Die Charité strebt eine Erhöhung des Anteils von Frauen in Führungspositionen an und fordert Frauen daher nachdrücklich auf, sich zu bewerben. Bei gleichwertiger Qualifikation werden Frauen im Rahmen der rechtlichen Möglichkeiten vorrangig berücksichtigt. Bewerbungen von Menschen mit Migrationshintergrund, die die Einstellungsvoraussetzungen erfüllen, sind ausdrücklich erwünscht. Schwerbehinderte Bewerber:innen werden bei gleicher Qualifikation bevorzugt. Bei der Einstellung wird ein polizeiliches Führungszeugnis, teilweise ein erweitertes Führungszeugnis verlangt. Die Bewerbungsunterlagen können leider nur dann zurückgeschickt werden, wenn ein ausreichend frankierter Rückumschlag beigefügt ist. Eventuell anfallende Reisekosten können nicht erstattet werden.