Research assistant / Doctoral candidate / PhD student Immunology Infectious Diseases Vaccination
Specialty
Infectiology
Work time
part-time
Start date
15.03.2026
Employment period
limited
Application deadline
28.02.2026
Deployment location Charité
Campus Virchow-Klinikum, Wedding
Jobcode
6549
Salary group
E13
Arbeiten an der Charité
The Giesecke-Thiel Lab investigates initiation, reactivation, and lifestyle of human B cell memory. This includes studying the immunological imprinting of human memory B cells from different antigen exposures, including both the nature of antigen and the anatomical site of priming. Our goal is to identify fundamental mechanisms of human immune memory and to leverage these discoveries to develop new ways to detect, prevent, and modify infection courses and outcomes.
Die Stelle im Überblick
In this project, the successful candidate will explore the phenotypic and molecular features of antigen-specific human memory B cells (mBCs) shaped by mucosal priming in comparison to systemic vaccinations. The candidate will optimize flow cytometry–based antigen-specific B cell stainings and phenotyping strategies and perform antigen-specific B cell stainings, flow cytometry analyses, and cell isolations using FACS and MACS to obtain high-quality antigen-specific populations.
A core responsibility includes establishing, benchmarking, and applying single-cell ATAC- and RNA-sequencing workflows (FLASH-seq), carried out in close collaboration with the local Core Facility. The candidate will additionally carry out basic bioinformatic analyses, including quality control, preprocessing, dimensionality reduction, and exploratory interpretation of single-cell multiomic datasets, with support from collaborating bioinformaticians.
A key task is to investigate how antigen challenges and rechallenges affect human memory B cells, thereby advancing our understanding of immune memory (re-)programming or its resilience to perturbation.
Danach suchen wir
Please provide a cover letter presenting your scienfici interests, why you want to do a doctorate and your goals and a curriculum vitae. Contact details of two willing referees for references. One letter of reference has to be included in the application.
Das bringt die Charité mit
Informationen zur Stelle
Everyone is welcome at the Charité, regardless of age, religion, gender, gender identity, sexual orientation, nationality, disability, ethnic or social background. We are committed to equal opportunities and inclusion.
Apply using our online tool and become part of the Charité.
Apply nowBei Fragen wenden Sie sich bitte an:
Dr. Claudia Giesecke-Thiel, claudia.giesecke-thiel@charite.de
The Charité would like to point out that personal data is stored and processed at various locations at the Charité premises (e.g. specialty department, personnel representatives, HR department) as part of and for the purposes of the application process. Furthermore, the data may be transferred or processed within the group and to external bodies (e.g. authorities) to protect legitimate interests. By submitting your application, you agree to our data protection policy and terms of use for application procedures, which you can find here.
Charité – Universitätsmedizin Berlin makes its personnel decisions based on suitability, ability and professional performance. The Charité aims to increase the proportion of women in management positions and therefore strongly encourages women to apply. Women with equivalent qualifications will be given priority within the scope of legal possibilities. Applications from people with a migration background who meet the recruitment requirements are expressly encouraged. Severely disabled applicants with equal qualifications will be given preference. A police good-conduct certificate, in some cases an extended good-conduct certificate, is required at the time of recruitment. Unfortunately, application documents can be returned only if a sufficiently stamped envelope is enclosed. Any incurred travel expenses cannot be reimbursed.