Postdoctoral Scientist / Microbiome - Bioinformatics Metagenomics and Metaproteomics
Start date
schnellst möglich
Application deadline
13.02.2026
Jobcode
6278
Salary group
E13
Working at Charité
The Ralser Lab at Charité – Universitätsmedizin Berlin investigates how cells control their metabolism on a large scale. With a focus on yeast, we use functional genomics and advanced mass spectrometry to study how genes and metabolic pathways interact. Our goal is to uncover basic principles of metabolism that are relevant for cancer, immunology, metabolic diseases, and clinical diagnostics.
As part of the ImmunoPreCept Cluster of Excellence, we here study how fungal commensals, especially Candida albicans, shape the immune system and contribute to inflammatory diseases such as Inflammatory Bowel disease (IBD). We combine proteomics, genomics, and computational methods, and we work with rich resources including prospective patient cohorts, a collection of 1,800 C. albicans strains, and cutting-edge proteomic technologies.
Overview of the position
In this project, we focus on microbiomes in general and on yeast commensals and IBD as inflammatory disease. Using metagenomics and metaproteomics, we aim to discover fungal commensals, such as the WHO priority pathogen Candida albicans, train the immune system and influence disease outcomes in inflammatory disease.
You will develop and apply cutting-edge computational approaches to:
- Map the human mycobiome by reanalyzing metagenomic datasets and processing clinical samples to identify yeast species and strain diversity
- Integrate multi-omics data (myco- and microbiome composition, metaproteomics, genomics, immune phenotypes) and support improved metaproteomic data analysis strategies
- Build predictors for identifying key fungal and host features determining resilience versus susceptibility to inflammation
- Establish standardized bioinformatics pipelines for fungal extraction, metaproteomics, and strain characterization while collaborating with wet-lab researchers, immunologists, and clinicians
What we are looking for
- PhD in bioinformatics, computational biology, systems biology, or related quantitative field
- Experience in microbiome data analysis (metagenomic/amplicon sequencing) and genome analysis (assembly, annotation, comparative genomics)
- Strong programming skills in Python and R, proficient in complex bioinformatics workflows
- Strong communication skills, ability to work in interdisciplinary teams, and proven publication track record
- Ability to work independently while collaborating across research groups
Charité offers you
- Being integrated into a large interdisciplinary team, with a focus on proteomics, proteome data analysis, and microbiome research
- Direct translational research opportunity with access to IBD patient cohorts, extensive C. albicans strain collection, and cutting-edge proteomics and single-cell platforms
- Interdisciplinary collaboration within the ImmunoPreCept Cluster of Excellence at one of Europe's largest research-intensive medical universities
- Access to high throughput technology, comprehensive training, and professional development opportunities
- High personal responsibility and scope for independent research
Information regarding the position
- Paygrade E13 according to TVöD VKA-K. Your job grade depends on your job qualification whereas the experience level depends on the number of working years. The yearly gross salary is hereby provided based on a full time position excluding yearly bonus and additional pay. You may find further information here: https://karriere.charite.de/tarifvertraege
- The working hours are full-time, with 38.5 hours per week
- This position is offered as a fixed-term contract until 31.01.2028, because it correlates with the project duration
- 30 days of paid vacation per year
- The application period ends on: 13.02.2026
- Position ID: 6278
Application
Everyone is welcome at the Charité, regardless of age, religion, gender, gender identity, sexual orientation, nationality, disability, ethnic or social background. We are committed to equal opportunities and inclusion.
Apply using our online tool and become part of the Charité.
Apply nowBei Fragen wenden Sie sich bitte an
Prof. Markus Ralser, E-mail: markus.ralser@charite.de
Dr. Alexandra Katharina Marr, E-mail: alexandra-katharina.marr@charite.de
More information
Data protection information
The Charité would like to point out that personal data is stored and processed at various locations at the Charité premises (e.g. specialty department, personnel representatives, HR department) as part of and for the purposes of the application process. Furthermore, the data may be transferred or processed within the group and to external bodies (e.g. authorities) to protect legitimate interests. By submitting your application, you agree to our data protection policy and terms of use for application procedures, which you can find here.
Additional information
Charité – Universitätsmedizin Berlin makes its personnel decisions based on suitability, ability and professional performance. The Charité aims to increase the proportion of women in management positions and therefore strongly encourages women to apply. Women with equivalent qualifications will be given priority within the scope of legal possibilities. Applications from people with a migration background who meet the recruitment requirements are expressly encouraged. Severely disabled applicants with equal qualifications will be given preference. A police good-conduct certificate, in some cases an extended good-conduct certificate, is required at the time of recruitment. Unfortunately, application documents can be returned only if a sufficiently stamped envelope is enclosed. Any incurred travel expenses cannot be reimbursed.