Post Doctoral Fellow (d/f/m) ERC FunChol 1

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Arbeitszeit
Vollzeit

Eintrittsdatum
01.05.2025

Dauer der Anstellung
Befristet

Bewerbungsfrist
08.04.2025

Einsatzort Charité
Campus Virchow-Klinikum, Wedding

Jobcode
4482

Entgeltgruppe
E13

Company describtion

The mission of the Berlin Institute of Health at Charité (BIH) is medical translation: transferring biomedical research findings into novel approaches to personalized prediction, prevention, diagnostics and therapies and, conversely, using clinical observations to develop new research ideas. The aim is to deliver relevant medical benefits to patients and the population at large. Since 2021 the BIH has been integrated into Charité as its so-called third pillar.

For the group Prof. Dr. Ludovic Vallier starting from the earliest possible date limited until 31.12.2029 we are looking for a Post Doctoral Fellow (d/f/m) in full-time (38,5h/week).

The Vallier Lab based at the BCRT will takes advantage of human induced pluripotent stem cells and primary organoids to understand liver development in human and to generate cells with a clinical interest for modelling diseases and for cell-based therapies applications. More precisely, the Vallier Lab investigates the molecular mechanisms controlling cell fate decisions during human development and exploits the resulting knowledge to produce liver cells, especially hepatocytes and cholangiocytes.

What you can expect

The candidate will join the ERC project FunChol which aims to uncover new mechanisms driving chronic liver disease and to identify targets for therapeutic development.
The role of the candidate will be to investigate the mechanisms by which acquisition of cellular plasticity during liver regeneration can lead to tumorigenesis.
For that you will derive, characterize and differentiate organoids from the liver of patient with chronic disease and perform genome editing using CRISPR/Cas9.
The resulting cell lines will be then characterized for their transcriptome, epigenetic state and somatic mutation signature using whole genome analyses.
Results obtained in vitro will be validated using fresh tissue samples and in vivo models for liver injury.

What you bring along

PhD or equivalent in stem cell biology and oncology.
Strong experience in tissue culture, especially with organoids derived from primary tissue, differentiation, and characterization.
Solid background in cancer biology and gastroenterology.
Experience with animal models for gastroenterology cancer.
Experience in flow cytometry, QPCR, expression profiling, confocal imaging, CRISPR/Cas9 genome editing, and ChIP-Seq.
Experience in working independently while keeping a strong team spirit.
At least one publication with first authorship.
Strong self-motivation, organizational skills, and ability to lead and develop scientific projects.

What we offer you

A varied job in a forward-looking research institute
Pay group E13 TVöD VKA-K. The classification is based on qualifications, the respective experience level is calculated on the basis of professional experience. The annual salary (gross) is stated for a full-time position without special or additional payments. The collective agreement can be found here.
Additional benefits customary in the public sector (including annual special payment, company pension scheme (VBL), capital-forming benefits)
Flexible working hours and the option of working remote
30 vacation days per year (with a five-day week)
Various support offers to balance work and family life (childcare, cooperation with voiio)
Very good training and further education opportunities
Mobile citizens' office on site
Corporate benefits (travel, leisure, shopping, etc.), Charité Gympass, JobRad
Very easily accessible and attractive workplace at the Föhrer Str. 15 in Campus Virchow-Klinikum, 13353 Berlin

We live diversity!

We welcome applications from people with diverse backgrounds, regardless of gender, nationality, ethnic and social origin, religion and ideology, disability, age, sexual orientation and identity. Applications from women are expressly encouraged. Severely disabled and equivalent applicants will be given special consideration if they have the same qualifications and suitability.
We believe that diverse teams representing a wide range of experiences, perspectives and backgrounds enrich our research and work.

Please submit your application via our online application form with a letter of motivation, curriculum vitae (without photo, without age statement and without information about your marital status) and other relevant attachments (such as employer references, degree certificates, etc.) by April 08th, 2025, quoting the reference number 4482.

Note: If you have a foreign degree, please submit proof of recognition of your degree in Germany with your application. The proof can be obtained via the anabin database. Please note that it may be necessary to obtain a certificate assessment from the ZAB. You can find more information here.

Proof of measles immunity / measles vaccination is a prerequisite for employment for those born after 1970.

You can find more information about BIH here.

Application

Apply using our online tool and become part of the Charité.

Apply now

Contact person

If you have any technical questions about the job posting, please contact Prof. Dr. Ludovic Vallier (Tel.: 030 450 539 498; e-mail: ludovic.vallier@bih-charite.de).

More information

Data protection information

The Charité would like to point out that personal data is stored and processed at various locations at the Charité premises (e.g. specialty department, personnel representatives, HR department) as part of and for the purposes of the application process. Furthermore, the data may be transferred or processed within the group and to external bodies (e.g. authorities) to protect legitimate interests. By submitting your application, you agree to our data protection policy and terms of use for application procedures, which you can find here.

Additional information

Charité – Universitätsmedizin Berlin makes its personnel decisions based on suitability, ability and professional performance. The Charité aims to increase the proportion of women in management positions and therefore strongly encourages women to apply. Women with equivalent qualifications will be given priority within the scope of legal possibilities. Applications from people with a migration background who meet the recruitment requirements are expressly encouraged. Severely disabled applicants with equal qualifications will be given preference. A police good-conduct certificate, in some cases an extended good-conduct certificate, is required at the time of recruitment. Unfortunately, application documents can be returned only if a sufficiently stamped envelope is enclosed. Any incurred travel expenses cannot be reimbursed.