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Doctoral Scientist (PhD) at the Clinic for Pediatric Endocrinology and Diabetology DM.247.24

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Doctoral Scientist (PhD) at the Clinic for Pediatric Endocrinology and Diabetology DM.247.24

Specialty
Endocrinology and diabetology

Charite Kampagne 1350x900 2 Entdeckung Bildschirm
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Work time
part-time

Start date
zum nächstmöglichen Zeitpunkt

Employment period
limited

Application deadline
14.02.2025

Deployment location Charité
Campus Virchow-Klinikum, Wedding

Jobcode
4082

Salary group
E13

 

Working at the Charité

The Department of Pediatric Endocrinology and Diabetology at the Charité-Universitätsmedizin Berlin (AG Kühnen) is looking for a motivated PhD in Bioinformatics starting 01.01.2025. The primary focus of our group’s research is on rare endocrine and metabolic diseases. Special topics include epigenetic mechanisms of the central regulation of body weight and thyroid hormone regulation of human brain development. To analyze the impact of genetic and epigenetic variants on hormonally regulated molecular pathways, our group’s translational research prioritizes experimental models based on human embryonic stem cells (hESC) and human induced pluripotent stem cells (hiPSC). The PhD project is associated to an ERC funded research project “E-VarEndo” and focused on the bioinformatic analysis of methylome-, ATAC seq-, ChIP-seq- and single cell/single-nucleus data, to address the question how epigenetic variability and transposable elements affect gene function and regulate the individual predisposition to devel.

Job Overview

The project is performed in close cooperation with the Berlin Institute of Health (BIH) Core Unit Bioinformatics (Head: Prof. Beule), leading to an optimal environment to perform the expected data analysis.
The candidate will focus on the topic of epigenetic regulation of body weight. This project specifically aims to investigate different layers of epigenetic regulation (DNA methylation, chromatin marks) and the interplay between genetic and epigenetic variation. A specific focus will be the identification of metastable epialleles, their relation to transposable elements and the impact of environmental cues on epigenetic variability. 

Core tasks relevant to the project include:

  • Bioinformatic analysis of complex genome-wide datasets (newly generated and publicly available), including methylome-, cut&tag, ATAC-seq, ChIP-seq, single-cell/single-nucleus data derived from primary samples and stem-cell derived model systems
  • Select and benchmark existing analysis tools and workflows
  • Develope new/ innovative approaches where existing tools are inadequate
  • Process large omics datasets, identify and efficiently integrate relevant public resources, contribute to data management and automation of processing and results reporting 
  • Contribute to the experimental design considerations, translate biomedical questions into bioinformatics approaches, and promote of interdiciplinary exchange between biomedical and bioinformatics researchers

Scientific employees are given sufficient time for their own scientific work based on their employment status.

Required

  • We are looking for an enthusiastic, talented and motivated bioinformatician (PhD candidate)
  • Bioinformatics experience in analyzing epigenetic/ genetic data and strong interest in close collaboration with basic researchers and physicians desirable
  • Master’s degree in bioinformatics, computational biology, mathematics, physics, or similar, with a track-record of successful scientific work
  • Ability to work in a highly collaborative environment both independently and as part of a team is essential
  • Motivation to participate in the training and supervision of young scientists (e.g. bachelor / rotation students) in addition to the scientific work
  • Good programming skills in R or python are expected and experience in creating and maintaining high-quality, readable codes
  • Excellent written and spoken English skills
  • Familiarity with bash / HPC environments, with workflow and version management (snakemake/git) and proficiency in multivariate statistics and (sparse) linear algebra is a strong plus

Advantages at the Charité

  • A highly professional collaboration within a motivated and interdisciplinary team
  • A future-oriented, varied and challenging job with high levels of personal responsibility and personal freedom of action
  • Inter-cultural team events, well-structured onboarding with friendly colleagues
  • Extensive free continuing education and training opportunities up to and including university studies
  • Discounts on various offerings for employees, for example shopping, travel, sports
  • Charité has been certified as a family-friendly university and family-friendly company since 2007

Job Information

  • Salary group E13 according to TVöD- VKA- K. The classification is based on qualification, the respective experience level is calculated from the years of professional experience. The annual salary (gross) is given for a full-time position without annual bonus, allowances and additional services. You can find the collective agreement here
  • The working time is part-time with 25 hours per week
  • At our company 30 days of vacation are standard
  • The position is limited to 3 years
  • The application deadline is on: 31.12.2024
  • Reference number: 4082

Application

 

Apply using our online tool and become part of the Charité.

Apply now

For further questions please contact:

Prof. Dr. Peter Kühnen
peter.kuehnen@charite.de

 

More information

Data protection information

The Charité would like to point out that personal data is stored and processed at various locations at the Charité premises (e.g. specialty department, personnel representatives, HR department) as part of and for the purposes of the application process. Furthermore, the data may be transferred or processed within the group and to external bodies (e.g. authorities) to protect legitimate interests. By submitting your application, you agree to our data protection policy and terms of use for application procedures, which you can find here.

Additional information

Charité – Universitätsmedizin Berlin makes its personnel decisions based on suitability, ability and professional performance. The Charité aims to increase the proportion of women in management positions and therefore strongly encourages women to apply. Women with equivalent qualifications will be given priority within the scope of legal possibilities. Applications from people with a migration background who meet the recruitment requirements are expressly encouraged. Severely disabled applicants with equal qualifications will be given preference. A police good-conduct certificate, in some cases an extended good-conduct certificate, is required at the time of recruitment. Unfortunately, application documents can be returned only if a sufficiently stamped envelope is enclosed. Any incurred travel expenses cannot be reimbursed.