Postdoc - Rare Disease Research at the institute for medical physics and biophysics DM.226.24
Specialty
Biophysics,
Medical physics
Work time
part-time
Start date
01.02.2025
Employment period
limited
Application deadline
31.12.2024
Deployment location Charité
Campus Charité Mitte
Jobcode
4057
Salary group
E13
Working at the Charité
We are looking for a highly motivated and committed postdoctoral candidate for the newly established laboratory of Dr. Sameer Singh at the Institute of Medical Physics and Biophysics. The main focus of the group is to understand the mechanisms that lead to the development of a class of rare diseases known as ribosomopathies. Ribosomopathies are a heterogeneous group of rare diseases caused by mutations in proteins involved in ribosome production or function. They manifest through distinct clinical characteristics, often involving bone marrow failure, skeletal abnormalities, and neurological defects. Additionally, ribosomopathy patients have a higher predisposition to developing cancer, highlighting the broad ways in which rare diseases impact human health. However, the precise mechanisms by which defects in ribosome production cause these clinical manifestations remain largely unknown.
Job Overview
We offer you access to state-of-the-art instrumentation and training facilities at the Charité Facility for in situ Structural Biology. Additionally, we also collaborate with experts at other distinguished institutions in the Berlin area on the analysis and integration of large-scale omics data. We aim to leverage these techniques to make fundamental discoveries in rare disease research. The laboratory will use high-resolution cryo-electron microscopy, high-throughput sequencing, and CRISPR/Cas9 editing as primary techniques to delineate the molecular mechanisms driving ribosomopathies. For more information on our structural and gene-editing approaches, please refer to: Singh et al., https://doi.org/10.1126/science.abj5338; Singh et al., https://doi.org/10.1038/s41598-023-28732-8
You will work in the project “The structural biology of disease: Using high resolution imaging to understand rare pathologies” and will have the following tasks within the project:
In accordance with § 110 BerlHG, academic staff are given sufficient time for their own academic qualification.
Required:
PhD in a relevant field (biology, life sciences)
Experience in wet lab work (cell biology, molecular biology, biochemistry)
Experience in cryo-EM/structural biology is an advantage
Experience in generating human cell lines using CRISPR/Cas is an advantage (but not a prerequisite)
Proficiency in English
Strong verbal and written communication skills, with the ability to work effectively in a collaborative team environment
We offer:
Advantages at the Charité
Job Information
Apply using our online tool and become part of the Charité.
Apply nowFor further questions please contact:
Dr. Sameer Singh
sameer-kumar.singh@charite.de
The Charité would like to point out that personal data is stored and processed at various locations at the Charité premises (e.g. specialty department, personnel representatives, HR department) as part of and for the purposes of the application process. Furthermore, the data may be transferred or processed within the group and to external bodies (e.g. authorities) to protect legitimate interests. By submitting your application, you agree to our data protection policy and terms of use for application procedures, which you can find here.
Charité – Universitätsmedizin Berlin makes its personnel decisions based on suitability, ability and professional performance. The Charité aims to increase the proportion of women in management positions and therefore strongly encourages women to apply. Women with equivalent qualifications will be given priority within the scope of legal possibilities. Applications from people with a migration background who meet the recruitment requirements are expressly encouraged. Severely disabled applicants with equal qualifications will be given preference. A police good-conduct certificate, in some cases an extended good-conduct certificate, is required at the time of recruitment. Unfortunately, application documents can be returned only if a sufficiently stamped envelope is enclosed. Any incurred travel expenses cannot be reimbursed.