Researcher or PhD position - Department of Pediatric Respiratory Medicine, Immunology and Critical Care Medicine DM.217.24
Specialty
Immunology,
Pneumology
Work time
part-time
Start date
01.01.2025
Employment period
limited
Application deadline
30.11.2024
Deployment location Charité
Campus Virchow-Klinikum, Wedding
Jobcode
3932
Salary group
E13
Working at the Charité
The underlying project ('Mucus-microbiota interplay in the lung') of this exciting doctoral postition is integrated into the DFG-funded Collaborative Research Centre (CRC) 1449 “Dynamic Hydrogels at Biointerfaces”, in which several research groups from Freie Universität Berlin and Charité-Universitätsmedizin Berlin investigate hydrogel properties and function at biological interfaces in health and disease. You can find further informations here
This project will investigate the interplay between the microbiota and the mucus in the lungs. It will also focus on evaluating the molecular mechanisms underlying the interaction with the immune system in order to gain a better understanding of muco-obstructive lung diseases, such as cystic fibrosis, and thereby improving treatment options in the long term.
Job Overview
We are seeking a highly motivated and committed doctoral candidate for a research project with the focus to elucidate the interplay of mucus and microbiota in health and disease. We aim to gain a better understanding of how the composition and activity of the airway microbiota impact or depend on biochemical/-physical properties of airway mucus.
For that purpose, the effects of specific mucins (mucus glycoporteins) on mucus properties and microbiota composition in the lung under both healthy and diseased conditions will be investigated using different mouse models. A better understanding of the composition, structure and function of the mucus hydrogel layer on airway surfaces and the impact of microbiota perturbances is key to elucidate the underlying disease mechanisms and to identify potential therapeutic targets for the development of novel therapies.
The tasks of the doctoral project include the performance of mouse experiments, the collection and analysis of biological material (e.g. by ELISA, qRT-PCR, Western Blot, flow cytometry, microbiome, transcriptomics). Further, we encourage the PhD candidate to present research findings at national and international conferences and to contribute to the preparation of manuscripts.
In addition, the PhD candidate will become a member of the CRC’s integrated Research Training Group, which offers, for example, various workshops for personal development and provides access to international research networks with the opportunity for research stays in collaborating laboratories (https://www.sfb1449.de/IRTG/).
Scientific staff is given sufficient time to carry out their own scientific work in accordance with their employment relationship (§ 110 BerlHG).
Required:
Advantages at the Charité
Job Information
Apply using our online tool and become part of the Charité.
Apply nowFor further questions please contact:
Dr. Nancy Freitag
paed-pneu-forschung@charite.de
The Charité would like to point out that personal data is stored and processed at various locations at the Charité premises (e.g. specialty department, personnel representatives, HR department) as part of and for the purposes of the application process. Furthermore, the data may be transferred or processed within the group and to external bodies (e.g. authorities) to protect legitimate interests. By submitting your application, you agree to our data protection policy and terms of use for application procedures, which you can find here.
Charité – Universitätsmedizin Berlin makes its personnel decisions based on suitability, ability and professional performance. The Charité aims to increase the proportion of women in management positions and therefore strongly encourages women to apply. Women with equivalent qualifications will be given priority within the scope of legal possibilities. Applications from people with a migration background who meet the recruitment requirements are expressly encouraged. Severely disabled applicants with equal qualifications will be given preference. A police good-conduct certificate, in some cases an extended good-conduct certificate, is required at the time of recruitment. Unfortunately, application documents can be returned only if a sufficiently stamped envelope is enclosed. Any incurred travel expenses cannot be reimbursed.