Specialty
Hematology and oncology
Work time
part-time
Start date
15.01.2027
Employment period
limited
Application deadline
13.11.2026
Deployment location Charité
Campus Charité Mitte
Jobcode
8434
Salary group
E13
Working at Charité
The Neumann Research Group is a young, translational research group at the Charité Comprehensive Cancer Center. Our research focuses on patient-derived tumor models, which we use to investigate mechanisms of therapeutic resistance and develop novel treatment strategies for patients with pancreatic ductal adenocarcinoma (PDAC).
PDAC is one of the cancers associated with the poorest prognosis. At the same time, the emergence of novel direct KRAS inhibitors offers, for the first time, the opportunity to therapeutically target a key oncogenic driver of pancreatic cancer. The rapid development of these compounds and their increasing evaluation in clinical trials have made understanding why tumors fail to respond to KRAS inhibitors, or respond only temporarily, a highly relevant challenge in translational cancer research.
In our research group, we combine clinically relevant questions with advanced preclinical tumor models. Our approaches include patient-derived organoids, functional drug testing, and genetic, transcriptomic, and proteomic analyses. A particular focus of this German Cancer Aid (Deutsche Krebshilfe)-funded project is to elucidate KRAS-dependent mechanisms of drug resistance in PDAC. To this end, we have access to an established biobank comprising 36 patient-derived PDAC organoid models representing, among others, different KRAS mutations. These models are used to investigate both intrinsic and acquired resistance to KRAS inhibitors.
The project is conducted in close scientific collaboration with Prof. Dr. Reinhold Schäfer from the Institute of Pathology at Charité. As a co-applicant on the project funded by German Cancer Aid, he contributes his expertise particularly in the molecular and pathological characterization and functional investigation of tumor models. This collaboration brings together the Neumann Research Group's expertise in patient-derived tumor models and functional drug testing with the complementary expertise of the Institute of Pathology.
Overview of the position
You will work as a Research Associate on a research project funded by German Cancer Aid (Deutsche Krebshilfe), focusing on elucidating KRAS-dependent mechanisms of drug resistance in pancreatic ductal adenocarcinoma (PDAC). As part of your Ph.D. research project in the natural sciences, you will investigate the molecular mechanisms underlying intrinsic and acquired resistance to KRAS inhibitors using an established biobank of 36 patient-derived PDAC organoid models.
Your key responsibilities will include:
This position offers the opportunity for further scientific qualification leading to a Ph.D. in the natural sciences. You will work in an interdisciplinary, translational research environment, addressing a clinically highly relevant research question. The overarching goal is to gain a deeper understanding of resistance mechanisms to KRAS inhibitors and to develop novel therapeutic combination strategies for pancreatic cancer.
What we are looking for
You enjoy experimental research, are interested in innovative approaches to translational cancer research, and are eager to contribute to the development of novel therapeutic strategies for pancreatic cancer. You are motivated to combine experimental and computational approaches, ideally have some initial hands-on research experience, and are keen to further develop your scientific and methodological skills as part of your doctoral studies.
We are therefore looking for a highly motivated and dedicated individual who meets the following requirements:
Charité offers you
Information regarding the position
Everyone is welcome at the Charité, regardless of age, religion, gender, gender identity, sexual orientation, nationality, disability, ethnic or social background. We are committed to equal opportunities and inclusion.
For data protection reasons, we only accept applications via our application portal. The contact details provided below are intended solely for inquiries.
Apply nowIf you have questions, please contact:
Dr. med. Christopher Neumann
E-Mail: christopher.neumann@charite.de
AG-Website: https://cccc.charite.de/forschung/arbeitsgruppen_ag/cccc_labs/ag_neumann
The Charité would like to point out that personal data is stored and processed at various locations at the Charité premises (e.g. specialty department, personnel representatives, HR department) as part of and for the purposes of the application process. Furthermore, the data may be transferred or processed within the group and to external bodies (e.g. authorities) to protect legitimate interests. By submitting your application, you agree to our data protection policy and terms of use for application procedures, which you can find here.
Charité – Universitätsmedizin Berlin makes its personnel decisions based on suitability, ability and professional performance. The Charité aims to increase the proportion of women in management positions and therefore strongly encourages women to apply. Women with equivalent qualifications will be given priority within the scope of legal possibilities. Applications from people with a migration background who meet the recruitment requirements are expressly encouraged. Severely disabled applicants with equal qualifications will be given preference. A police good-conduct certificate, in some cases an extended good-conduct certificate, is required at the time of recruitment. Unfortunately, application documents can be returned only if a sufficiently stamped envelope is enclosed. Any incurred travel expenses cannot be reimbursed.