PhD Student (d/f/m) Personalisation of In-Silico Models for Predicting Thrombosis Risk in Medical Devices
Specialty
Biomedicine,
Cardiology
Work time
full-time
Start date
01.09.2026
Employment period
limited
Application deadline
31.03.2026
Deployment location Charité
Campus Virchow-Klinikum, Wedding
Jobcode
6324
Working at the Charité
At the Institute of Computer-assisted Cardiovascular Medicine at the Charité – Universitätsmedizin Berlin (Germany), a PhD-position is available within the ThromboRisk project, a Marie Sklodowska-Curie Actions (MSCA) Doctoral Network funded by the EU. The position is open for appointment during the course of 2026, with a duration of 36 months, and includes up to 12 months of secondment to other partners of the network.
Overview of the position
Do you want to be trained to develop multi-level thrombosis risk prediction models by integrating cell-, thrombus-, and organ-level insights? While being part of a prestigious MSCA doctoral network working on revolutionizing personalized medicine through cutting-edge in silico, in vitro, and in vivo technologies to understand, predict and treat thrombosis? This is your chance!
As Doctoral Candidate, your first goal will be to establish a robust in-vitro framework. You will conduct microfluidic experiments using patient-specific blood samples to mimic Platelet Function Analyzer tests. This involves setting up channels with varied surface coatings and utilizing micro-CT to image thrombus formation and channel closure. A second goal will consist of creating a "Digital Twin" of these experiments. You will fit numerical thrombus growth models to the experimental data using advanced optimization strategies and neural network surrogates. Ultimately, you will apply these personalized parameters to simulate and assess thrombosis risk in Ventricular Assist Devices.
Research Programme Description
The ThromboRisk – European Doctoral Network titled 'From cells to systems: Pioneering multi-level thrombosis risk prediction models' is funded by the European Union under Grant Agreement No. 101227706. It groups 10 hiring universities: Eindhoven University of Technology (NL), University of Maastricht (NL), University of Amsterdam (NL), Catholic University Leuven (BE), Charité – Universitätsmedizin Berlin (DE), University College London (UK), Transsilvania University of Brasov (RO), SANO Centre for Computational Personalized Medicine (PL), University of Leeds (UK), and University of Bern (CH). Two projects are hosted by the Charité – Universitätsmedizin Berlin.
ThromboRisk will develop an integrated platform to advance our understanding of thrombosis across biological scales, combining mechanobiology, biochemistry, pathophysiology, and computational modelling. For this inclusion to occur, each DC will develop through their research a unique contribution to the multi-level thrombosis risk prediction framework, addressing specific aspects of thrombus formation, growth, rupture, and clinical impact. This hands-on training is supplemented with several scientific professional courses and an immersive training program where the DCs can fine-tune their skills for the jobs of tomorrow, while addressing the societal challenges of the ThromboRisk program.
What we are looking for
We are looking for a candidate who meets the following requirements:
What the Charité offers
A meaningful job in an interdisciplinary setting and within an international network. The Charité – Universitätsmedizin Berlin is an internationally renowned university hospital with a rich history. In addition, we offer you:
Information regarding the position
Eligibility criteria
Supported researchers must be doctoral candidates, i. e. not already in possession of a doctoral degree at the date of the recruitment.
Recruited researchers can be of any nationality and must comply with the following mobility rule: they must not have resided or carried out their main activity (work, studies, etc.) in Germany for more than 12 months in the 36 months immediately before their recruitment date. Compulsory national service, short stays such as holidays and time spent by the researcher as part of a procedure for obtaining refugee status under the Geneva Convention are not considered.
Everyone is welcome at the Charité, regardless of age, religion, gender, gender identity, sexual orientation, nationality, disability, ethnic or social background. We are committed to equal opportunities and inclusion.
Apply using our online tool and become part of the Charité.
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Please contact the local PIs Leonid Goubergrits (leonid.goubergrits@dhzc-charite.de) or Jan Brüning (jan.bruening@dhzc-charite.de).
How To Apply
Candidates possessing both suitable experience and qualifications are invited to apply. The application should include:
The Charité would like to point out that personal data is stored and processed at various locations at the Charité premises (e.g. specialty department, personnel representatives, HR department) as part of and for the purposes of the application process. Furthermore, the data may be transferred or processed within the group and to external bodies (e.g. authorities) to protect legitimate interests. By submitting your application, you agree to our data protection policy and terms of use for application procedures, which you can find here.
Charité – Universitätsmedizin Berlin makes its personnel decisions based on suitability, ability and professional performance. The Charité aims to increase the proportion of women in management positions and therefore strongly encourages women to apply. Women with equivalent qualifications will be given priority within the scope of legal possibilities. Applications from people with a migration background who meet the recruitment requirements are expressly encouraged. Severely disabled applicants with equal qualifications will be given preference. A police good-conduct certificate, in some cases an extended good-conduct certificate, is required at the time of recruitment. Unfortunately, application documents can be returned only if a sufficiently stamped envelope is enclosed. Any incurred travel expenses cannot be reimbursed.