Postdoctoral researcher (d/f/m) Cardiometabolic HFpEF / Interorgan crosstalk

Specialty
Cardiology

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Work time
full-time

Start date
Zum nächstmöglichen Zeitpunkt

Employment period
limited

Application deadline
06.02.2026

Deployment location Charité
Campus Charité Mitte

Jobcode
6251

Salary group
E13

Arbeiten am Deutschen Herzzentrum der Charité

We are looking for a highly motivated and talented postdoctoral researcher to join our translational cardiometabolic research team, which focuses on heart failure with preserved ejection fraction (HFpEF), metabolism and organ interaction. The position is part of a DZHK-funded partner project entitled: ‘Linking metabolic organ interaction in HFpEF: The interplay between heart, liver and adipose tissue’. This project addresses one of the most pressing challenges in modern cardiovascular medicine: the increasing burden of cardiometabolic HFpEF caused by metabolic disorders in the liver and adipose tissue.

The successful candidate will work in the rich scientific environment of the DHZC, MDC and DZHK and will have access to state-of-the-art multi-omics platforms, advanced cardiovascular phenotyping and extensive clinical and biobank resources. This field offers significant career advantages:

the opportunity to work in a current, clinically relevant research area with strong European and global visibility
direct integration into large interdisciplinary networks (DZHK, CRC1470, UK Biobank collaborations)
a path to high-impact publications and competitive grants
a translational environment that connects mechanistic biology → human cohorts → therapeutic innovations

Die Stelle im Überblick

You will conduct mechanistic studies to investigate metabolic flows, lipotoxicity and inter-organ signalling between the liver, adipose tissue and heart, and present the results at national and international conferences
You will apply multi-omics approaches (transcriptomics, proteomics, metabolomics) in preclinical models of HFpEF (HFD+L-NAME, targeted interventions) and evaluate translational interventions (GLP-1 receptor agonists, FGF21 agonists, calorie restriction, cold exposure) in terms of their cardiometabolic and hepatic effects
You will identify hepatokines and adipokines that influence cardiac remodelling using TurboID proximity labelling, metabolic assays (Seahorse, Oroboros) and advanced imaging
You will collaborate with bioinformaticians to integrate population-based analyses from HFpEF cohorts and the UK Biobank
You will participate in the discovery of biomarkers and precision medicine strategies within the CRC1470 and DZHK clinical platforms

You will be employed as a researcher: According to §110 (4), sentence 3, the BerlHG requires researchers to have an appropriate amount of time during their working hours for their own further scientific qualification.

We are looking for a highly motivated scientist with great potential for independence and excellence

You have a PhD in molecular biology, cardiovascular biology, metabolic biology, bioinformatics or a related field
You have at least one publication as first author in an internationally recognised journal as well as strong motivation, scientific creativity, and commitment to high-quality research
You have extensive experience in wet lab work (cell culture, molecular assays, animal experiments)
You have excellent written and oral communication skills in English
Experience in one or more of the following areas is a great advantage: bioinformatics/computer-assisted analysis, mass spectrometry, NGS/epigenetic approaches, metabolic phenotyping.
Furthermore, you have the ability to work in a multidisciplinary and international team.

What the Charité offers

A future-oriented, varied and challenging role with a high degree of personal responsibility and freedom to act
Intercultural team events, well-structured onboarding with friendly colleagues
Extensive free training and development opportunities
Discounts on many offers for employees in the areas of shopping, travel and sport
Certified as a family-friendly university and family-friendly company since 2007 (further information can be found here)

Information regarding the position

Paygrade E13 according to TVöD VKA-K. Your job grade depends on your job qualification whereas the experience level depends on the number of working years. The yearly gross salary is hereby provided based on a full time position excluding yearly bonus and additional pay. You may find further information here
This full time position is limited until 31 August 2028.
The application period ends on 6 February 2026
Position ID: 6251

Application

Everyone is welcome at the Charité, regardless of age, religion, gender, gender identity, sexual orientation, nationality, disability, ethnic or social background. We are committed to equal opportunities and inclusion.

Apply using our online tool and become part of the Charité.

Apply now

If you have questions, please contact:

Saskia Diezel
AG Schiattarella
saskia.diezel@dhzc-charite.de

More information

Data protection information

The Charité would like to point out that personal data is stored and processed at various locations at the Charité premises (e.g. specialty department, personnel representatives, HR department) as part of and for the purposes of the application process. Furthermore, the data may be transferred or processed within the group and to external bodies (e.g. authorities) to protect legitimate interests. By submitting your application, you agree to our data protection policy and terms of use for application procedures, which you can find here.

Additional information

Charité – Universitätsmedizin Berlin makes its personnel decisions based on suitability, ability and professional performance. The Charité aims to increase the proportion of women in management positions and therefore strongly encourages women to apply. Women with equivalent qualifications will be given priority within the scope of legal possibilities. Applications from people with a migration background who meet the recruitment requirements are expressly encouraged. Severely disabled applicants with equal qualifications will be given preference. A police good-conduct certificate, in some cases an extended good-conduct certificate, is required at the time of recruitment. Unfortunately, application documents can be returned only if a sufficiently stamped envelope is enclosed. Any incurred travel expenses cannot be reimbursed.