PhD Student (d/f/m) for translational Myeloma Research

Specialty
Hematology and oncology

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Work time
part-time

Start date
zum nächstmöglichen Zeitpunkt

Employment period
limited

Application deadline
06.11.2025

Deployment location Charité
Campus Benjamin Franklin, Steglitz

Jobcode
5499

Salary group
E13

Working at Charité

We are looking for a highly qualified and motivated scientist to pursue a Ph.D. in the field of translational myeloma research.
Our research group is a young, interdisciplinary, and innovative team consisting of physicians and scientists from biology, chemistry, biochemistry, and bioinformatics. We work in state-of-the-art laboratories with access to all common technologies. We place great emphasis on structured scientific mentoring and successful onboarding. Our research is currently funded by the Hector Foundation, the Else Kröner-Fresenius Foundation, and the German Research Foundation (DFG). The project builds on extensive preliminary work in which we developed a novel single-cell sequencing technology for the analysis of genome-wide cancer screens. This technology will now be applied to a comprehensive functional screen and complemented by multiple state-of-the-art technologies and validation platforms.

Overview of the position

Translational PhD project focused on identifying biomarkers that enable early prevention and prediction of the progression from myeloma precursor stages to active disease
Development and evaluation of targeted therapeutic strategies for patients with hard-to-treat myeloma
Perform a genome-wide cancer screen in CCND1- and MMSET-deregulated plasma cell tumors in a mouse model
Characterize resulting tumors in depth using a broad spectrum of bulk and single-cell analyses, with close collaboration and synergies with a parallel single-cell project from our group at the BIMSB
Validate the most promising candidate genes involved in myelomagenesis using preclinical models
Conduct subsequent mechanistic studies and translate findings into the human disease context, with the possibility of independently performing bioinformatic analyses
Application of a wide range of methods and technologies: mouse experiments, single-cell analyses, RNA/DNA sequencing, protein biochemistry, flow cytometry, CRISPR-Cas9 gene editing, bioinformatics/data science
Work with diverse model systems: genetically modified preclinical models (including mice), cell lines, primary patient material, and patient datasets
You are engaged in scientific work, and in accordance with §110 (4) sentence 3 of the BerlHG (Berlin Higher Education Act), an appropriate amount of time is granted to you for your own scientific qualification

What we are looking for

Master’s degree (or equivalent) in biology, biochemistry, molecular medicine, computational biology, pharmacy, bioengineering, or a related field
High motivation, strong commitment, and excellent communication skills
Solid knowledge of molecular and cell biology
Excellent proficiency in English, both written and spoken
Desirable: prior experience with preclinical models (e.g., FELASA certificate) and/or bioinformatic analyses

Charité offers you

Highly professional work environment in motivated and interdisciplinary teams
A future-oriented, varied and demanding position with a high grade of personal responsibility and personal decision making opportunities
Special offers in the areas of shopping, travel and sports
Additional pension program with a company wide pension scheme
Certification as a family friendly university and company since 2007 - You may find further information here

Information regarding the position

Paygrade E13 according to TVöD VKA-K. Your job grade depends on your job qualification whereas the experience level depends on the number of working years. The yearly gross salary is hereby provided based on a full time position excluding yearly bonus and additional pay. You may find further information here
Working hours: 25 hours per week
The position is limited until 31.10.2028, as it is tied to the project duration
30 days of paid vacation per year
The application period ends on: 06.11.2025
Position ID: 5499

Application

Everyone is welcome at the Charité, regardless of age, religion, gender, gender identity, sexual orientation, nationality, disability, ethnic or social background. We are committed to equal opportunities and inclusion.

Apply using our online tool and become part of the Charité.

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If you have questions, please contact:

Jasmin Radenkovic

jasmin.radenkovic@charite.de

More information

Data protection information

The Charité would like to point out that personal data is stored and processed at various locations at the Charité premises (e.g. specialty department, personnel representatives, HR department) as part of and for the purposes of the application process. Furthermore, the data may be transferred or processed within the group and to external bodies (e.g. authorities) to protect legitimate interests. By submitting your application, you agree to our data protection policy and terms of use for application procedures, which you can find here.

Additional information

Charité – Universitätsmedizin Berlin makes its personnel decisions based on suitability, ability and professional performance. The Charité aims to increase the proportion of women in management positions and therefore strongly encourages women to apply. Women with equivalent qualifications will be given priority within the scope of legal possibilities. Applications from people with a migration background who meet the recruitment requirements are expressly encouraged. Severely disabled applicants with equal qualifications will be given preference. A police good-conduct certificate, in some cases an extended good-conduct certificate, is required at the time of recruitment. Unfortunately, application documents can be returned only if a sufficiently stamped envelope is enclosed. Any incurred travel expenses cannot be reimbursed.