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Research assistant at the Insitute of Rheumatology and Clinical Immunology DM.56.24

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Research assistant at the Insitute of Rheumatology and Clinical Immunology DM.56.24

Specialty
Rheumatology

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Work time
part-time

Start date
Ab 01.05.2025

Employment period
limited

Application deadline
04.04.2025

Deployment location Charité
Campus Charité Mitte

Jobcode
4487

Salary group
E13

 

Working at the Charité

Aim of the project: The aim of this doctoral thesis is to develop an in vitro test battery for the preclinical evaluation of new osteoporosis therapeutics. The test battery will serve as an alternative to animal testing and help to significantly reduce the number of animal experiments required. The aim is to test both the efficacy and safety of new active substances, taking into account endpoints in accordance with the requirements of the Food and Drug Administration (FDA) and the European Medicines Agency (EMA).

Job Overview

Methodology:

  • Establishment and optimization of an in vitro bone model to simulate osteoporotic conditions (preliminary work available)
  • Isolation, cultivation and differentiation of human mesenchymal stromal cells/ osteoblasts and monocytes/osteoclasts (preliminary work available)
  • Investigation of the effects of potential therapeutics on bone cells using modern cell biology and molecular biology methods (e.g. qPCR, Western blot, immunofluorescence staining, immunoassays, µCT) (some preliminary work available)
  • Integration of 3D cell culture techniques and co-culture systems in modern bioreactor setups for physiological imaging of the bone microenvironment (some preliminary work available)
  • Validation of the test battery using established reference substances


We offer:

  • An interdisciplinary and collaborative research environment
  • Modern equipped laboratories with access to highly specialized analytical techniques
  • Intensive supervision of the doctorate by experienced scientists
  • Opportunity to complete a doctorate (PhD, Dr. rer. nat.) in the context of an exciting and socially relevant research topic
  • Possibility to embed the work in a PhD program (DRS, BCRT)
  • Support through further scientific training and conference attendance
  • You are scientifically active: According to § 110 (4), sentence 3, the BerlHG provides scientific employees with an appropriate amount of time within their working hours for their own further scientific qualification

Required:

  • Completed university degree (Master's degree or equivalent) in biology, biochemistry, biotechnology or a related field
  • Very good knowledge of flow cytometry, qPCR analysis and cell culture
  • Experience with cell culture techniques and 3D models, molecular biology methods, cell biology analyses, on-a-chip systems
  • Interest in translational research and alternative methods to animal testing
  • This is a collaborative project with the Bf3R, which requires an independent, structured way of working and a strong ability to work in a team
  • Very good written and spoken English skills

Advantages at the Charité

  • A highly professional collaboration within a motivated and interdisciplinary team
  • A future-oriented, varied and challenging job with high levels of personal responsibility and personal freedom of action
  • Inter-cultural team events, well-structured onboarding with friendly colleagues
  • Extensive free continuing education and training opportunities up to and including university studies
  • Discounts on various offerings for employees, for example shopping, travel, sports
  • Charité has been certified as a family-friendly university and family-friendly company since 2007

Job Information

  • Salary group E13 according to TVöD- VKA- K. The classification is based on qualification, the respective experience level is calculated from the years of professional experience. The annual salary (gross) is given for a full-time position without annual bonus, allowances and additional services.
  • The working time is part-time with 25 hours per week
  • At our company 30 days of vacation are standard
  • The position is limited until 31.03.2028, as it is tied to the project duration
  • The application deadline is on: 28.03.2025
  • Reference number: 4487

Application

 

Apply using our online tool and become part of the Charité.

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For further questions please contact:

moritz.pfeiffenberger@charite.de

 

More information

Data protection information

The Charité would like to point out that personal data is stored and processed at various locations at the Charité premises (e.g. specialty department, personnel representatives, HR department) as part of and for the purposes of the application process. Furthermore, the data may be transferred or processed within the group and to external bodies (e.g. authorities) to protect legitimate interests. By submitting your application, you agree to our data protection policy and terms of use for application procedures, which you can find here.

Additional information

Charité – Universitätsmedizin Berlin makes its personnel decisions based on suitability, ability and professional performance. The Charité aims to increase the proportion of women in management positions and therefore strongly encourages women to apply. Women with equivalent qualifications will be given priority within the scope of legal possibilities. Applications from people with a migration background who meet the recruitment requirements are expressly encouraged. Severely disabled applicants with equal qualifications will be given preference. A police good-conduct certificate, in some cases an extended good-conduct certificate, is required at the time of recruitment. Unfortunately, application documents can be returned only if a sufficiently stamped envelope is enclosed. Any incurred travel expenses cannot be reimbursed.