PhD student - DM.138.24

Specialty
Immunology, Hematology and oncology

Charite Kampagne 1350x900 5 Entdeckung 1

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Work time
part-time

Start date
zum nächstmöglichen Zeitpunkt

Employment period
limited

Application deadline
09.08.2024

Deployment location Charité
Campus Benjamin Franklin, Steglitz

Jobcode
3503

Salary group
E13

Working at the Charité

We are seeking a highly qualified and motivated scientist to join our team for a Ph.D. in translational lymphoma research. Our young, interdisciplinary team of physicians and scientists from biology, biochemistry, and bioinformatics has a strong publication record and is dedicated to advance cancer research.
Join a dynamic team in modern laboratories shared by five research groups, where innovation thrives. Work with state-of-the-art technologies (flow cytometry, protein biochemistry, genomics) and top instruments (automated pipetting systems, high-content Operetta imaging platform). Benefit from ongoing collaborations with single-cell multi-omics, genomics, and proteomics experts at BIMSB, MDC, and BIH. Receive successful onboarding and structured scientific guidance to support your research.

Job overview

In your Ph.D. project, you will investigate the immune-cold tumor microenvironment (TME) in aggressive B cell lymphoma to identify genetic drivers and biomarkers to develop novel pharmacological combination therapies aimed at enhancing cancer immunity.

Build a High-Resolution Immune Cell Landscape: Develop a detailed immune cell profile of our primary lymphoma patient cohort to identify biomarkers impacting the TME
Establish Genetic Models for Biomarker Testing: Create and utilize genetic models to explore the effects of your biomarker on the efficacy of novel immunotherapies
Validate Treatment Strategies in Preclinical Models: Test biomarker-informed immunotherapuetic strategies using preclinical mouse models

In this project, you will utilize techniques such as flow cytometry, protein biochemistry, CRISPR/Cas9 gene-editing and sequencing-technologies with the possibility to perform independent bioinformatical analysis. On top, you will learn to apply advanced spectral flow cytometry techniques and engage in single-cell multi-omics through collaborations. You will work with diverse models, including primary patient material, cell lines, patient datasets, and mouse models.

Scientific staff is given sufficient time to carry out their own scientific work in accordance with § 110 BerlHG.

We are looking for

Educational Background: You should hold a degree in Biology, Biochemistry, Molecular Medicine, Pharmacy, Bioengineering, or a related field
Background in Molecular and Cell Biology Expertise: A strong foundation in molecular and cell biology is preferred
Pre-Clinical Models and NGS Experience: Ideally, experience with pre-clinical models (e.g., FELASA certificate) and proficiency in analyzing data from standard NGS platforms is advantageous
Language Skills: Excellent English skills are required; knowledge of German is a plus
Communication and Teamwork: Strong communication skills, experience working in multidisciplinary teams, and a record of working in competitive research environments are highly valued
A thorough knowledge of our recent research work is required for the application process (please review PMID 35499080 and 35022408)

Advantages at the Charité

Highly professional collaboration in a motivated and interdisciplinary team
A future-oriented, varied and challenging job with a high degree of personal responsibility and scope for personal action
Intercultural team events, well-structured onboarding with friendly colleagues
Discounts on many offers for employees in the areas of shopping, travel and sport
Our company pension scheme provides our employees with additional security in old age

Job Information

Pay grade E13 TVöD VKA-K. The classification is based on qualifications, the respective experience level is calculated on the basis of years of service. The annual salary (gross) is stated for a full-time position without annual bonus, allowances and additional services. You can find the collective agreement here
The working time is part-time 25.4 hours
30 days vacation are standard with us
The application deadline ends on: 13.09.2024
Reference number: 3503

Application

Apply using our online tool and become part of the Charité.

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For questions please contact:

uta.demel@charite.de

More information

Data protection information

The Charité would like to point out that personal data is stored and processed at various locations at the Charité premises (e.g. specialty department, personnel representatives, HR department) as part of and for the purposes of the application process. Furthermore, the data may be transferred or processed within the group and to external bodies (e.g. authorities) to protect legitimate interests. By submitting your application, you agree to our data protection policy and terms of use for application procedures, which you can find here.

Additional information

Charité – Universitätsmedizin Berlin makes its personnel decisions based on suitability, ability and professional performance. The Charité aims to increase the proportion of women in management positions and therefore strongly encourages women to apply. Women with equivalent qualifications will be given priority within the scope of legal possibilities. Applications from people with a migration background who meet the recruitment requirements are expressly encouraged. Severely disabled applicants with equal qualifications will be given preference. A police good-conduct certificate, in some cases an extended good-conduct certificate, is required at the time of recruitment. Unfortunately, application documents can be returned only if a sufficiently stamped envelope is enclosed. Any incurred travel expenses cannot be reimbursed.