Working at the Charité
We are seeking a highly qualified and motivated scientist to join our team for a Ph.D. in translational lymphoma research. Our young, interdisciplinary team of physicians and scientists from biology, biochemistry, and bioinformatics has a strong publication record and is dedicated to advance cancer research.
Join a dynamic team in modern laboratories shared by five research groups, where innovation thrives. Work with state-of-the-art technologies (flow cytometry, protein biochemistry, genomics) and top instruments (automated pipetting systems, high-content Operetta imaging platform). Benefit from ongoing collaborations with single-cell multi-omics, genomics, and proteomics experts at BIMSB, MDC, and BIH. Receive successful onboarding and structured scientific guidance to support your research.
Job overview
In your Ph.D. project, you will investigate the immune-cold tumor microenvironment (TME) in aggressive B cell lymphoma to identify genetic drivers and biomarkers to develop novel pharmacological combination therapies aimed at enhancing cancer immunity.
- Build a High-Resolution Immune Cell Landscape: Develop a detailed immune cell profile of our primary lymphoma patient cohort to identify biomarkers impacting the TME
- Establish Genetic Models for Biomarker Testing: Create and utilize genetic models to explore the effects of your biomarker on the efficacy of novel immunotherapies
- Validate Treatment Strategies in Preclinical Models: Test biomarker-informed immunotherapuetic strategies using preclinical mouse models
In this project, you will utilize techniques such as flow cytometry, protein biochemistry, CRISPR/Cas9 gene-editing and sequencing-technologies with the possibility to perform independent bioinformatical analysis. On top, you will learn to apply advanced spectral flow cytometry techniques and engage in single-cell multi-omics through collaborations. You will work with diverse models, including primary patient material, cell lines, patient datasets, and mouse models.
Scientific staff is given sufficient time to carry out their own scientific work in accordance with § 110 BerlHG.
Advantages at the Charité
- Highly professional collaboration in a motivated and interdisciplinary team
- A future-oriented, varied and challenging job with a high degree of personal responsibility and scope for personal action
Intercultural team events, well-structured onboarding with friendly colleagues
- Discounts on many offers for employees in the areas of shopping, travel and sport
- Our company pension scheme provides our employees with additional security in old age